Nextflow Frontier / Seqera Gradient cyp2d6 predictor: self-training SVM. Saved predictions from stim-exp20260-cyp2d6-selftraining-svm-c9e2d4d995bd/trial_0009, selected score 0.7602844473934859. The method and trial were selected using repeated feedback from the fixed test scorer. Retained evidence does not establish independent held-out evaluation; lineage, scorer-access and isolation questions remain unresolved. This is an adaptive benchmark result, not an independent held-out generalization claim. Original pipeline replay was not performed for this submission. Saved predictions were aligned by exact molecular inputs, including duplicate multiplicities and equal duplicate predictions and re-evaluated with the official Polaris evaluator. Class predictions use a fixed 0.5 threshold for additional metrics.